Acid Phosphatase 1 Proteins

Protein Information

Low molecular weight protein tyrosine phosphtases, including the human red cell phosphatase, HCPTP, are widely expressed cytosolic proteins of approximately 18 kDa that exist in distinct isoforms and are highly selective for phosphotyrosine over phosphoserine or phosphotyrosine. The HCPTP-A and HCPTP-B proteins expressed in human red cells and placenta are fast and slow forms of red cell acid phosphatase5. Like other tyrosine phosphatases, HCPTP is sensitive to inhibition by vanadate, and has a catalytic mechanism that involves formation of a cystinylphosphate intermediate6. The crystal structure of the bovine heart derived enzyme BHPTP shows a four-stranded central parallel b sheet with flanking a helices and an active site cysteine residue in the typical tyrosine phosphatase sequence context, CXXXXXR.

Synonyms

4632432E04Rik; acid phosphatase; acid phosphatase 1; acid phosphatase 1, soluble; acid phosphatase of erythrocyte; ACP1; Acp-1; Adipocyte acid phosphatase; AI427468; cytoplasmic phosphotyrosyl protein phosphatase; HAAP; HAAP betaÊ; LMW-PTP; LMW-PTPase; LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1; Low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase; MGC111030; MGC3499; phosphatase 1, soluble; protein tyrosine phosphatase; ptpase; red cell acid phosphatase 1; testicular secretory protein Li 37; Unknown (protein for MGC:128334)